Recent Publications

Bardet-Biedl Syndrome Proteins Modulate the Release of Bioactive Extracellular Vesicles.

Volz A-K, Frei A, Kretschmer V, de Jesus Domingues A M, Ketting RF, Ueffing M, Boldt K, Krämer-Albers E-M, May-Simera HL
2021 Nat. Com. DOI: 10.1038/s41467-021-25929-1

Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts.

PEintracht J, Forsythe E, May-Simera H, Moosajee M
2021 EBioMedicine. 70:103515

The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis.

Bayer F, Dremova O, Khuu MP, Mammadova K, Pontarollo G, Kiouptsi K, Soshnikova N, May-Simera HL, Endres K, Reinhardt C
2021 Nutrients. 13(7):2198

Loss of Ciliary Gene Bbs8 Results in Physiological Defects in the Retinal Pigment Epithelium.

Schneider S, De Cegli R, Nagarajan J, Kretschmer V, Matthiessen PA, Intartaglia D, Hotaling N, Ueffing M, Boldt K, Conte I and May-Simera HL
2021 Front. Cell Dev. Biol. 9:607121

Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines.

Weißbach S, Sys S, Hewel C, Todorov H, Schweiger S, Winter J, Pfenninger M, Torkamani A, Evans D, Burger J, Everschor-Sitte K, May-Simera HL, Gerber S
2021 BMC Genomics 22(1):62

The entangled relationship between cilia and actin.

Brücker L, Kretschmer V, May-Simera HL
2020 Int J Biochem Cell Biol. 129:105877

Tissue-dependent differences in Bardet-Biedl syndrome gene expression.

Patnaik SR, Farag A, Brücker L, Volz AK, Schneider S, Kretschmer V, May-Simera HL
2020 Biol Cell 112(2):39-52

The Role of WNT Signaling During Ciliary-Dependent RPE Development.

Kretschmer V, May-Simera HL
2020 Klin Monbl Augenheilkd 237(3):248-258

Progressive characterization of visual phenotype in Bardet-Biedl Syndrome mutant mice.

Kretschmer V, Kretschmer F, Patnaik SR, Chwada M, Hernandez-Hernandez V, May-Simera HL
2019 IOVS 1;60(4):1132-1143

Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.

Patnaik SR, Kretschmer V, Brücker L, Schneider S, Volz AK, Oancea-Castillo LDR, May-Simera HL
2018 Cell Mol Life Sci. 76(4):757-775

Generation of an inducible RPE-specific Cre transgenic-mouse line.

Schneider S, Hotaling N, Campos M, Patnaik SR, Bharti K, May-Simera HL
2018 PLoS One. 15;13(11):e0207222

Primary Cilium Mediated Retinal Pigment Epithelium Maturation is Retarded in Ciliopathy Patient Cells.

May-Simera H L, Wan Q, Jha BS, Hartford J, Khristov V, Dejene R, Chang J, Patnaik S, Lu Q, Banerjee P, Silver J, Insinna-Kettenhofen C, Patel D, Lotfi M, Malicdan M, Hotaling N, Maminishkis A, Sridharan R, Brooks B, Miyagishima K, Gunay-Aygun M, Pal R, Westlake C, Miller S, Sharma R, Bharti K
2018 Cell Rep. Jan 2;22(1):189-205

Cilia - The sensory antennae in the eye.

May-Simera H, Nagel-Wolfrum K, Wolfrum U
2017 Prog. Retin. Eye Res. 60:144-180

Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.

May-Simera HL, Gumerson JD, Gao C, Campos M, Cologna SM, Beyer T, Boldt K, Kaya KD, Patel N, Kretschmer F, Kelley MW, Petralia RS, Davey MG, Li T
2016 Cell Rep. 17(5):1399-1413

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea.

May-Simera H
2016 J Vis Exp. 21;(108)

Ciliary proteins Bbs8 and Ift20 regulate planar cell polarity in the cochlea.

May-Simera HL, Petralia R, Montcouquiol M, Wang YX, Szarama K, Liu Y, Lin W, Deans MR, Pazour G, Kelley MW
2014 Development. 1;142(3):555-66